Biohybrid Microrobots: A New Frontier in Targeted Drug Delivery and Precision Therapeutics

Biohybrid microrobots, integrating living biological components with synthetic materials, represent a cutting-edge approach to advancing medical treatments, particularly in drug delivery. These microrobots leverage natural biological systems, such as bacteria, algae, or mammalian cells, in combination with synthetic components like nanoparticles and polymers to achieve targeted, efficient, and responsive therapeutic delivery. Key mechanisms like pH sensitivity, temperature responsiveness, and enzyme-triggered release enhance their ability to release drugs precisely at the site of need, offering solutions for localized therapy and reducing side effects. Despite their promising applications, challenges related to biocompatibility, stability, scalability, and regulatory concerns remain. Future advancements, including enhanced propulsion systems, AI integration, and improved targeting mechanisms, hold the potential to overcome these hurdles. Biohybrids are poised to revolutionize drug delivery, disease diagnosis, tissue repair, and regenerative medicine, offering a new frontier in personalized and efficient healthcare.

Keywords: Biohybrid Microrobots, Targeted Drug Delivery, Drug Release Mechanisms, Bacterial-Powered Microrobots Enzyme-Triggered Release.